Integrative computational modeling of protein interactions

Computational prediction of protein-protein interactions.

The prediction of protein-protein interactions and kinase-specific phosphorylation sites on individual proteins is critical for correctly placing proteins within signaling pathways and networks. The importance of this type of annotation continues to increase with the continued explosion of genomic and proteomic data, particularly with emerging data categorizing posttranslational modifications o...

Computational Prediction of Protein-Protein Interactions

Recently a number of computational approaches have been developed for the prediction of protein-protein interactions. Complete genome sequencing projects have provided the vast amount of information needed for these analyses. These methods utilize the structural, genomic and biological context of proteins and genes in complete genomes to predict protein interaction networks and functional linka...

Computational design of protein-protein interactions.

A long-term aim of computational design is to generate specific protein-protein interactions at desired affinity, specificity, and kinetics. The past three years have seen the first reports on atomically accurate de novo interactions. These were based on advances in design algorithms and the ability to harness high-throughput experimental characterization of design variants to optimize binding....

Computational prediction of protein-protein interactions

Introduction: Structural biology and molecular biology are complementary approaches that are able to inform our mechanistic understanding of biological systems. For technical reasons, our understanding of proteins and their interactions has primarily come by way of molecular biology. However, our knowledge of high-resolution crystal structures is growing as evidenced by the many entries into th...

Computational Modeling of Laser-Cell Biochemical Interactions